With SpamAssassin (SA), it's important to note that there are server wide settings and there are settings for individual mailboxes.
Server wide settings are simple enough to get to.  Log in using the plesk interface and from the navigation column, select server and then select the spamassassin icon. If you wish to enable server wide settings, check the box for server wide settings.
Let's talk about the hits required number - also known as the sensitivity or threshold.  SpamAssassin works by assigning a point value for each characteristic an email message has that's indicative of spam (for example Viagra, or "make $$$ from home", etc.). When a particular message's spam value reaches the threshold number then it is marked as spam.
The default value of 7 is very high.  It is recommended that server wide settings be enabled and the required number to lowered to a value of 3 or 4.
Now let's talk about individual mailbox SA (SpamAssassin) settings.  We will use mailuser@some_domain.com to show you how to do this.
From the navigation menu, select domains, then select the domain you wish to work with (in this example, it's some_domain.com).  Then select the mail icon under services.  Then click on the mailbox you wish to modify.
From there select the mailbox icon under tools.  On the next screen place a check in the box next to Enable spam filtering and save the settings.
This will enable the Spam filter icon and the SA on/off link.
Now select the spam filter icon.  This will take you to a screen to configure threshold number as well as other features (remember the default value of 7 is very high - a value 3 or 4 is recommended).
Last, but not least, SA needs to be trained.  Select the training icon.
This will take you to a screen that allows you to see the headers of messages in this mailbox.  Ones that you recognise as obviously being spam, you should check the select box and then click the link for "It's spam."

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